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OpenTechBio builds open-source AI systems that automate the full lifecycle of biological research — from hypothesis generation to autonomous experiment execution, powered by multi-agent orchestration and HPC infrastructure.
System Evolution
Not a Tool. A Research Engine.
A deliberate progression from ideation assistant to fully autonomous scientific discovery platform.
Biodesign Buddy
The ideation and education layer. Helps researchers explore literature, generate hypotheses, and scaffold biotech design ideas through RAG-powered AI.
OLAF
Open Life Science Analysis Platform. Proved that LLMs can execute real biological analysis — translating natural language into reproducible bioinformatics workflows.
CARIBOU
The autonomous research engine. CLI-based, HPC-native, multi-agent system that orchestrates full scientific pipelines with minimal human intervention.
Core System
CARIBOU
Computational AI Research Interface for Bioinformatics,
Omics, and Unifying Agents
CARIBOU transforms LLMs from passive tools into active research operators — orchestrating multi-agent pipelines across HPC environments to execute complete, reproducible scientific workflows at scale.
Design Philosophy
Built for Science at Scale
Automation First
Remove manual steps entirely. Replace fragmented workflows with intelligent agents that execute end-to-end research loops.
Composability
Modular pipelines and reusable components that stack seamlessly across research domains and compute environments.
Execution Over Chat
Not just generating ideas — actually running experiments. Real outputs, real data, real reproducibility.
Scientific Rigor
Every step traced, every output auditable. Reproducibility and verifiability are first-class system requirements.
Projects
The OpenTechBio Ecosystem
CARIBOU
PrimaryThe autonomous research engine at the heart of OpenTechBio. CARIBOU orchestrates multi-agent scientific workflows across HPC environments, chaining reasoning steps into full, reproducible research pipelines — with no manual bottlenecks.
OLAF
OriginOpen Life Science Analysis Platform. The prototype that proved LLMs can execute real bioinformatics — translating natural language into runnable pipelines with structured outputs.
Biodesign Buddy
GatewayThe ideation and education layer. Expands who can participate in biotech innovation through literature retrieval, novelty analysis, and hypothesis scaffolding.
Who It's For
Help Build the Future of Autonomous Science
OpenTechBio is fully open-source. Contribute to CARIBOU, OLAF, or Biodesign Buddy — and help build the infrastructure powering the next generation of biological research.